The southern Great Xing’an Range (SGXR), located in the southeastern part of Inner Mongolia, China, shows intense Mesozoic tectono-magmatic activity and hosts economically important polymetallic (Cu–Pb–Zn–Sn–Fe–Ag–Au–Mo) mineralization. Here, we present new zircon U–Pb ages, whole-rock geochemical data, Nd–Sr–Hf isotopic data and Re–Os ages for the Taibudai deposit in the SGXR. The Taibudai granitoids show high SiO 2 (70.62–72.13wt.%) and alkali (Na 2 O+K 2 O=7.04–8.60wt.%) concentrations, low MgO (0.89–1.37wt.%) and Al 2 O 3 (∼14wt.%), ASI ratios <1.1 (0.94–0.97), LILEs (e.g., Rb) enriched, HFSEs (e.g., Nb, Ta, Ti, and P) depleted, and have low Sr and Yb concentrations, classifying these rocks as fractionated I-type granites. The Taibudai granitoids have negative ε Nd (t) values ranging from −2.2 to −1.6 and relatively low initial 87 Sr/ 86 Sr ratios from 0.70536 to 0.70581. In situ Hf isotopic analyses on zircons using LA–MC–ICP–MS show variable positive ε Hf (t) values ranging from +0.80 to +13.55, corresponding to relatively young two-stage Hf model ages from 801 to 942Ma (excluding one spot). These mineralogical, geochemical, and isotopic features strongly suggest that the primary magmas of the Taibudai granitoids were derived mainly from the partial remelting of Neoproterozoic juvenile crustal material, with no remarkable modification through incorporation of continental or subduction-related material. Re–Os isotope analyses of molybdenite from the deposit yield an ore-forming age of 137.1±1.4Ma. Re contents range from 4.37 to 41.77ppm, implying ore material components have a mixed crust–mantle origin. SHRIMP analysis of zircons show that the monzogranitic porphyry and biotite granite in the Taibudai deposit were formed at 137.0±0.9Ma and 138.3±0.9Ma, respectively, indicating a temporal link between granitic magmatism and Cu mineralization. This result, combined with the regional geology, tectonic evolution, and age data from the literature, suggests that the Early Cretaceous (∼140Ma) was the peak metallogenic epoch for the Great Xing’an Range, and the mineralization in this period generally takes the form of porphyry, skarn, or hydrothermal polymetallic ore deposits in an active extensional continental margin environment. The Taibudai porphyry and associated mineralization provides a typical example of magmatism and metallogeny associated with a Paleo-Pacific plate subduction, continental margin, back-arc extensional setting.