Evaluation of CF bone disease presence and identification of its risk factors in our CF children population. Study included 68 children with cystic fibrosis, aged 10.2 to 18.8 years, genotyped and monitored in the National CF Centre, for 2 years. At the annual assessment, besides clinical examination, biochemical evaluation for pancreatic insufficiency, diabetes liver disease, a subgroup of 26 children were evaluated for bone mineral density using dual energy x-ray absorptiometry (DXA). Detection of body mass density – BMD (g/cm 2 ) – by DXA was determined on lumbar spinal (L1-L4). The age-corrected BMD findings were expressed as Z scores and correlated with gender, nutritional status (BMI), pancreatic insufficiency, genotype and presence of related diabetes. Twenty-six patients, aged over 10 years were diagnosed with CF bone disease, signifying a cumulative prevalence of 38.2%, without significant gender gap. The average Z score for BMD was –2.55. Bone disease was frequent in patients aged over 10 years with exocrine pancreatic insufficiency RR = 1.37 (95% CI 1.044–1.804), p = 0.02, carriers of severe mutations (RR = 1.51; 95% CI 1.054–2.187) and CF liver disease. CF children carriers of a severe genotype who associates pancreatic insufficiency and CF liver disease were more likely predisposed to low bone mineral density. Further studies should discover other significant influences in order to prevent the development of CF bone disease and an improved life quality in cystic fibrosis children.