A two-stage oxidation (UV-Na 2 S 2 O 8 /H 2 O 2 -Fe(II,III)) process was applied to mineralize bisphenol A (BPA) at pH i (initial pH) 7. We take advantage of the high oxidation potential of sulfate radicals and use persulfate as the 1st-stage oxidant to oxidize BPA to less complex compounds (stoichiometric ratio: [S 2 O 8 2− ] 0 /[BPA] 0 =1). Afterwards, the traditional photo-Fenton process was used to mineralize those compounds to CO 2 . To the best of our knowledge, this is the first attempt to utilize the two processes in conjunction for the complete degradation of BPA. During the 2nd-stage reaction, other oxidants (H 2 O 2 and Iron alone) were also employed to observe the extent of enhancement of photo-Fenton. Further, qualitative identification of both hydroxyl and sulfate radicals was performed to evaluate their dominance under different conditions. The BPA degradation in this UV/persulfate process formulated a pseudo-first-order kinetic model well, with a rate constant of approximately 0.038min −1 (25°C), 0.057min −1 (35°C), and 0.087min −1 (50°C), respectively. The much lower activation energy (ΔE=26kJmol −1 ) was further calculated to clarify that the thermal-effect of an illuminated system differs from single heat-assisted systems described in other research. Final total organic carbon (TOC) removal levels of BPA by the use of such two-stage oxidation processes were 25–34%, 25%, and 87–91% for additional Fe(II,III) activation, H 2 O 2 promotion, and Fe(II,III)/H 2 O 2 promotions, respectively.