This study quantitatively analyzes the relationship between the material structure (powder characteristics) and flow properties of highly filled compounds. The model parameters are the powder particle-size distribution and its volume fraction in a compound. The simulated material structure is developed using the Hard Spheres Model, from which the structural functions in terms of the statistical distribution of inter-particle distances and the histograms of effective volumes of groups of close particles are calculated. A close similarity between simulated and real functions was obtained. The results obtained imply that numerical modeling might serve as a reliable and sensitive approach for analyzing the influence of powder particle-size distribution on the ability to process highly filled compounds.