In this paper, we report experimental results of photoluminescence (PL) of nanopatterned organic light-emitting diode (OLED). Nanosphere lithography is used to create the nanopatterns. Comparing the emission of the OLED from regions with and without the nanopatterns, the PL intensity resulting from the regions with the nanopatterns is increased by 43%. In addition, we also observed that the PL intensity is increased ∼6 times if the organic active layer is deposited on the nanopatterns and covered by a thin metal film of Al. This strong increase of PL intensity may be attributed to surface plasmon effects.