To evaluate the prevalence and associated factors of androgen deficiency (AD) in men with lower urinary tract symptoms (LUTS).From November 2011 to March 2012 in a single institute, we enrolled 122 men with LUTS. AD was defined as having a total testosterone level less than 3 ng/mL. The underlying disease and associated factors related to AD were analyzed with univariate and multivariate methods.Of the 122 patients, 55.3% reported having AD. The AD group had a larger waist circumference (WC) and higher blood white cell count (WBC) in the univariate analysis but in multivariate analysis, only WC >90 cm was an independently associated factor of AD (OR: 2.864, p = 0.042).A considerable portion of men with LUTS had AD. The major associated factor of AD was WC >90 cm. WC should thus be measured routinely in men with LUTS and physicians should pay more attention to those with WC >90 cm in order to identify and treat these patients earlier to improve symptoms of LUTS and life quality.