Developmental Cell

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ERK and MMPs Sequentially Regulate Distinct Stages of Epithelial Tubule Development

Lucy Erin O'Brien, Kitty Tang, Ellen S Kats, Amy Schutz-Geschwender, more

Developmental Cell > 2004 > 7 > 1 > 21-32

Epithelial cells undergo tubulogenesis in response to morphogens such as hepatocyte growth factor (HGF). To organize into tubules, cells must execute a complex series of morphogenetic events; however, the mechanisms that underlie the timing and sequence of these events are poorly understood. Here, we show that downstream effectors of HGF coordinately regulate successive stages of tubulogenesis. Activation...

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Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature

Jesús Torres-Vázquez, Aaron D Gitler, Sherri D Fraser, Jason D Berk, more

Developmental Cell > 2004 > 7 > 1 > 117-123

Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sensed by migrating neuronal growth cones through plexin receptors. We show that proper blood vessel pathfinding...

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The PDGF/VEGF Receptor Controls Blood Cell Survival in Drosophila

Katja Brückner, Lutz Kockel, Peter Duchek, Carlos M Luque, more

Developmental Cell > 2004 > 7 > 1 > 73-84

The Drosophila PDGF/VEGF receptor (PVR) has known functions in the guidance of cell migration. We now demonstrate that during embryonic hematopoiesis, PVR has a role in the control of antiapoptotic cell survival. In Pvr mutants, a large fraction of the embryonic hemocyte population undergoes apoptosis, and the remaining blood cells cannibalistically phagocytose their dying peers. Consequently, total...

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The Mitochondrial Morphology Protein Mdm10 Functions in Assembly of the Preprotein Translocase of the Outer Membrane

Chris Meisinger, Michael Rissler, Agnieszka Chacinska, Luiza K.Sanjuán Szklarz, more

Developmental Cell > 2004 > 7 > 1 > 61-71

The biogenesis of mitochondrial outer membrane proteins involves the general translocase of the outer membrane (TOM complex) and the sorting and assembly machinery (SAM complex). The two known subunits of the SAM complex, Mas37 and Sam50, are required for assembly of the abundant outer membrane proteins porin and Tom40. We have identified an unexpected subunit of the SAM complex, Mdm10, which is involved...

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Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling

Satoru Torii, Morioh Kusakabe, Takuya Yamamoto, Momoko Maekawa, more

Developmental Cell > 2004 > 7 > 1 > 33-44

Spatiotemporal control of the Ras/ERK MAP kinase signaling pathway is among the key mechanisms for regulating a wide variety of cellular processes. In this study, we report that human Sef (hSef), a recently identified inhibitor whose action mechanism has not been fully defined, acts as a molecular switch for ERK signaling by specifically blocking ERK nuclear translocation without inhibiting its activity...

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A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish

Koichi Kawakami, Hisashi Takeda, Noriko Kawakami, Makoto Kobayashi, more

Developmental Cell > 2004 > 7 > 1 > 133-144

We report here development of a novel gene trap method in zebrafish using the Tol2 transposon system. First, we established a highly efficient transgenesis method in which a plasmid DNA containing the Tol2 transposon vector and the transposase mRNA synthesized in vitro were coinjected into one-cell stage embryos. The transposon vector inserted in the genome could be transmitted to the F1 progeny at...

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Thirteen Is the Lucky Number for Doublecortin

Anna Akhmanova, Fedor Severin

Developmental Cell > 2004 > 7 > 1 > 5-6

Doublecortin is a microtubule-associated protein that is essential for normal brain development. A recent report published in Molecular Cell shows that doublecortin associates preferentially with microtubules made of 13 protofilaments, by recognizing a novel site between the protofilaments. These findings explain how doublecortin stabilizes microtubules and provide clues about its function during...

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Step by Step

Marta Rosário, Walter Birchmeier

Developmental Cell > 2004 > 7 > 1 > 3-5

Branched hollow tubes form the architectural basis of many mammalian organs. The growth factor HGF/SF and its receptor, the Met receptor tyrosine kinase, stimulate epithelial cells to undergo tubulogenesis in vitro. In this issue of Developmental Cell, O'Brien et al. (2004) look at temporal regulation and the role of two HGF/SF effectors, the ERK 1/2 MAP kinases and matrix metalloproteases, in this...

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Caspases and Caspase Inhibitors on the Move

G.Paolo Dotto, John Silke

Developmental Cell > 2004 > 7 > 1 > 2-3

It is becoming clear that “apoptotic” caspases can effect cellular processes other than cell death. A recent paper in Cell points to a novel role of the Drosophila caspase inhibitor DIAP1 as a determinant of cell migration.

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Anterior Neuroectodermal Specification by Attenuating Cellular Responsiveness to Wnt Signaling

Takayuki Onai, Noriaki Sasai, Masaru Matsui, Yoshiki Sasai

Developmental Cell > 2004 > 7 > 1 > 95-106

Here we show that XsalF, a frog homolog of the Drosophila homeotic selector spalt, plays an essential role for the forebrain/midbrain determination in Xenopus. XsalF overexpression expands the domain of forebrain/midbrain genes and suppresses midbrain/hindbrain boundary (MHB) markers and anterior hindbrain genes. Loss-of-function studies show that XsalF is essential for the expression of the forebrain/midbrain...

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Timing and Checkpoints in the Regulation of Mitotic Progression

Patrick Meraldi, Viji M Draviam, Peter K Sorger

Developmental Cell > 2004 > 7 > 1 > 45-60

Accurate chromosome segregation relies on the precise regulation of mitotic progression. Regulation involves control over the timing of mitosis and a spindle assembly checkpoint that links anaphase onset to the completion of chromosome-microtubule attachment. In this paper, we combine live-cell imaging of HeLa cells and protein depletion by RNA interference to examine the functions of the Mad, Bub,...

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Semaphorins Guide PerPlexeD Endothelial Cells

Urban Deutsch

Developmental Cell > 2004 > 7 > 1 > 1-2

Abrogation of the endothelial cell-specific semaphorin receptor PlexinD1 in zebrafish and mouse reveals semaphorin functions selectively affecting the cardiovascular system. Neuropilins team up with PlexinD1 to form a novel endothelial receptor complex for class 3 semaphorins.

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PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development

Aaron D Gitler, Min Min Lu, Jonathan A Epstein

Developmental Cell > 2004 > 7 > 1 > 107-116

The identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality in newborn children worldwide. Signals mediated by semaphorin ligands and plexin receptors contribute to the intricate patterning of axons in the central nervous system. Here, we describe a related signaling...

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Mechanisms of Myotube Guidance and Attachment Site Selection

Frank Schnorrer, Barry J Dickson

Developmental Cell > 2004 > 7 > 1 > 9-20

The complex muscle patterns of higher organisms arise as migrating myoblasts are guided toward and connect with specific attachment sites. We review here the current understanding of myotube migration, focusing on its dynamic nature and the few molecular cues that have been identified to date. Much of this knowledge comes from studies in Drosophila, where powerful methods for in vivo imaging and genetic...

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Evidence for Tension-Based Regulation of Drosophila MAL and SRF during Invasive Cell Migration

Kálmán Somogyi, Pernille Rørth

Developmental Cell > 2004 > 7 > 1 > 85-93

Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and...

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h-ERES-y in ER-Golgi Transport

Elizabeth Brandon, Elizabeth Sztul

Developmental Cell > 2004 > 7 > 1 > 6-8

A debate continues over whether the Golgi is a stable organelle or a transient manifestation of continuous membrane flow from specialized ER exit domains (ERES). A new study from daSilva and colleagues shows that in plant cells, individual Golgi always form adjacent to an existing ERES, and that an ERES and its associated Golgi stack move as a single secretory unit. Their results support a model in...

article

Control after the Initiation of Translation

Arie Koen Braat, Nan Yan, Eric Arn, Dianne Harrison, more

Developmental Cell > 2004 > 7 > 1 > 125-131

The appearance of Oskar protein occurs coincident with localization of oskar mRNA to the posterior pole of the Drosophila oocyte, and earlier accumulation of the protein is prevented by translational repression. We find that the nascent polypeptide-associated complex (NAC) is required for correct localization of oskar mRNA. The timing of the defects suggests that, if NAC acts directly via an interaction...

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Developmental Cell

ERK and MMPs Sequentially Regulate Distinct Stages of Epithelial Tubule Development

Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature

The PDGF/VEGF Receptor Controls Blood Cell Survival in Drosophila

The Mitochondrial Morphology Protein Mdm10 Functions in Assembly of the Preprotein Translocase of the Outer Membrane

Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling

A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish

Thirteen Is the Lucky Number for Doublecortin

Step by Step

Caspases and Caspase Inhibitors on the Move

Anterior Neuroectodermal Specification by Attenuating Cellular Responsiveness to Wnt Signaling

Timing and Checkpoints in the Regulation of Mitotic Progression

Semaphorins Guide PerPlexeD Endothelial Cells

PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development

Mechanisms of Myotube Guidance and Attachment Site Selection

Evidence for Tension-Based Regulation of Drosophila MAL and SRF during Invasive Cell Migration

h-ERES-y in ER-Golgi Transport

Control after the Initiation of Translation

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