SNPs, DNA sequence alterations at a single nucleotide position, present useful advantages over other markers for forensic purposes. The most important advantage is the analysed DNA sequence size, which is much shorter than the one used for STR research. Therefore, SNP profiles could have an application in filiations and individual identification, especially in anthropology where samples are old and often degraded. The aim of this study is the selection of a panel of informative SNPs and the confirmation of their transmission on unrelated French paternity cases. SNPs being biallelic, the analysis of about 50 of them is necessary to obtain the discrimination power of the existing STR multiplexes. We selected a set of informative SNPs and optimised their amplification through multiplex (6-10 fragments) reactions. Pools of two to three loci are analysed simultaneously using MALDI-TOF mass spectrometry. We consider automatic analysis and profile-sample attribution through collaboration with Bruker Daltonique (France). Besides applying these markers to paternity cases, we also evaluate selected SNPs on different populations in order to evaluate population specific frequency data.