Establishing the neuropsychological effects of organic solvent exposure has been complicated by uncertainty regarding the length and extent of patients' exposure, variations in their premorbid medical histories, and incomplete neuropsychological studies. Much of the literature has focused on the acute effects of exposure; whether or not exposure results in an identifiable constellation of chronic neuropsychological deficits merits further study. We present the results of comprehensive neuropsychological examinations of three patients who were exposed to an organic solvent mixture containing Benzene, Toluene, and Xylene over an approximate 3- to 5-week period. They were exposed via inhalation and direct skin contact to approximately 90 times the recommended threshold limit values set by OSHA. All were seen for full neuropsychological evaluations approximately 7-months postexposure, were of approximately the same age and educational level, and had essentially negative medical histories. Results revealed a highly similar constellation of findings including evidence of diminished higher executive functions, greater learning than declarative memory deficits, and diminished upper extremity motor function in the presence of relatively preserved IQ. Results suggest that organic solvents may have a particular affinity for lipid rich tissue resulting in greater toxicity to subcortical regions.