This paper presents an expert system which derives differential diagnosis about epilepsy cases in childhood, according to international classifications. This expert system is intended to be used as a consultation system by neurologists. The physician specialist can update the knowledge base of the system through a user-friendly interface. Uncertainty is handled by using weights and certainty factors. Meta-rules drive the reasoning process of the system. The initial evaluation results of the system are very promising, i.e. 83.3% successful diagnosis.