Leading researcher-practitioners in the assessment and treatment of chronic fatigue syndrome (CFS) were invited to provide a case conceptualization and formulate a treatment plan for a client diagnosed with this syndrome. Common themes in the three responses are summarized, and a synopsis of the actual treatment process is also presented. In general, the case conference demonstrates the complexity of CFS, and that individuals with this syndrome require an individualized and integrative approach to cognitive-behavioral therapy that addresses both medical and psychological aspects of the illness. Cognitive-behavioral therapy can serve as an important component of a client's overall treatment, building coping skills and facilitating the lifestyle changes necessary to improve overall life quality. Respondents appeared to view the client as severely and legitimately disabled and as having an understandably difficult time coping with his illness.