This review describes the most popular architectures and transduction strategies that have been proposed for the development of electrochemical immunosensors. Relative published work has been classified into four main categories: i) enzyme-labelled immunosensors, ii) metal nanoparticle- and quantum dot-labelled immunosensors, iii) capacitive and (faradic) impedimetric immunosensors, and iv) magnetoimmunosensors. The principle of operation, analytical features, various signal amplification strategies as well as the adaptability of the afore-mentioned types of immunosensors to multiplexed formats, (micro) fluidic platforms and paper-based approaches are critically discussed. Perspectives in point-of-care analysis and commercialization opportunities are also discussed.