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A growing literature documents the important influence of organismic factors such as sex and genotype on pain sensitivity and pain modulation. We recently determined that 3-min forced swims in 15°C water produce non-opioid (i.e., naloxone-insensitive) analgesia in outbred Swiss–Webster mice of both sexes; this form of stress-induced analgesia (SIA) is significantly attenuated by the N-methyl-d-aspartate...
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