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An active disease mouse model of pemphigus vulgaris (PV) was developed using the adoptive transfer of splenocytes from Dsg3 −/− mice with a mixed C57BL/6J (B6) and 129/Sv genetic background into B6-Rag2 −/− mice. Further immunological investigation is needed to resolve the genetic mismatch between host and recipient mice. The B6-Dsg3 −/− mice did not grow old enough to provide...
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