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We previously demonstrated that the hyperpigmentation that occurs in UVB-melanosis as well as in solar lentigos is associated with the increased production of melanogenic cytokines, such as endothelin (EDN)-1 and stem cell factor (SCF), by keratinocytes in those areas of the skin.We developed a model for these hyperpigmentary disorders in EDN1+SCF stimulated human epidermal equivalents (HEEs) and...
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