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Human dermal fibroblasts are known to express the α, δ, , and ζ isoforms of protein kinase C (PKC). We asked whether the growth of human dermal fibroblasts correlates with expression of a particular PKC isoform. Of total PKC activity measured in the presence of calcium, a condition permissive for activation of all PKC isoforms, 75% was contributed by PKC-α, suggesting that PKC-α is the dominant...
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