Primary biliary cirrhosis (PBC) is an uncommon disease of as yet unknown origin, which affects mainly women, and has been found in association with autoimmune diseases, such as scleroderma, systemic lupus erythematosus, and others. Radiographs of the hands have been recommended by O'Connell DJ et al. (1978) as the most reliable in the demonstration of the bony changes in PBC. The radiographic features were mainly of erosions of the cortex associated with narrowing of the proximal and distal interphalangeal, and metacarpal-phalangeal joints with soft tissue swelling. A small periosteal new bone formation, an acro-osteolysis with soft tissue reabsorption, and cortical erosions with sclerotic margins of the carpal bones were also noted. In one case, a man of 62 years of age, radiographs of the right shoulder showed also destructive arthropathy, osseous collapse, flattening and sclerosis with marked narrowing of the glenohumeral joint. Two cases are reported and the roentgen findings are presented together with a detailed discussion of the radiological changes.