Treatment of brewery slurry in a thermophilic anaerobic sequencing batch reactor (ASBR) was studied using conventional fully mixed semi-continuous digestion as a control. The process phases were adapted to fit the brewery slurry discharge schedule. ASBR experiments were conducted under different organic loading rates (OLR) from 3.23 to 8.57kg of COD/m 3 day of reactor and control was conducted with OLR of 3.0kg of COD/m 3 day. The ASBR COD degradation efficiency was from 79.6% to 88.9%, control experiment efficiency was 65%. ASBR VSS removal efficiency was from 78.5% to 90.5%, control experiment efficiency was 54%. The ASBR methane production yield was from 371 to 418L/kg COD inserted, control experiment methane yield was 248L/kg COD inserted. The ASBR process was superior to conventional fully mixed digestion, and is fully adaptable to brewery slurry discharge, needs no additional collection and settling pools and experiences no solids settling problems.