Three nanorod-amino acid phosphomolybdates (nanorod-AA-PMo 12 ) (HGly) 3 [PMo 12 O 40 ]·(Gly) 9 (nanorod-Gly-PMo 12 , 1), (HLys) 3 [PMo 12 O 40 ]·(Lys) 4 ·9H 2 O (nanorod-Lys-PMo 12 , 2) and (HHis) 3 [PMo 12 O 40 ]·(His) 3 ·H 2 O (nanorod-His-PMo 12 , 3), were prepared by the solvent-thermo technique, using reverse micelles as a template, and characterized by transmission electron microscopy (TEM), FT-IR spectroscopy, X-ray diffraction (XRD), cyclic voltammetry (CV), elemental analysis and thermogravimetric analysis (TGA). Antibacterial experiments of the nanorod-AA-PMo 12 against Escherichia coli indicated remarkable activity. The {nanorod-Gly-PMo 12 /PEI} n films were also prepared (PEI = polyethyleneimine) and their antibacterial activity was studied which exhibited potential of solid antimicrobial.