We derive Laplace approximations to three functions of matrix argument which arise in statistics and elsewhere: matrix Bessel A ν ; matrix Bessel B ν ; and the type II confluent hypergeometric function of matrix argument, Ψ. We examine the theoretical and numerical properties of the approximations. On the theoretical side, it is shown that the Laplace approximations to A ν , B ν and Ψ given here, together with the Laplace approximations to the matrix argument functions 1 F 1 and 2 F 1 presented in Butler and Wood (Laplace approximations to hyper-geometric functions with matrix argument, Ann. Statist. (2002)), satisfy all the important confluence relations and symmetry relations enjoyed by the original functions.