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A Streptomyces fed-batch fermentation was studied with on-line measurement of dissolved carbon dioxide (DCO 2 ). A selected cell strain R060107 of Streptomyces hygroscopicus was used in the production of rapamycin. pH was controlled only in the production phase at the low limit of 5.1 after its value dropped from an initial 6.5 to 5.1. DCO 2 was used to control the feed in the fed-batch...
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