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This review is focused on the mechanism of ubiquinol oxidation by the cytochrome bc 1 complex (bc 1 ). This integral membrane complex serves as a “hub” in the vast majority of electron transfer chains. The bc 1 oxidizes a ubiquinol molecule to ubiquinone by a unique “bifurcated” reaction where the two released electrons go to different acceptors: one is accepted by the mobile...
A recent review [H.Tedeschi, Old and New Data, New Issues: the Mitochondrial Δψ, Biochim. Biophys. Acta, Bioenerg. (2005)] has questioned the validity of experiments performed more than 30 years ago that provided the first quantitative estimates of the protonmotive force generated by mitochondria. This commentary explains that the review author's confusion stems from ignoring the data in these papers...
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