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The availability of the results of high-throughput analyses coming from ‘omic’ technologies has been one of the major driving forces of pathway biology. Analytical pathway biology strives to design a ‘pathway search engine’, where the input is the ‘omic’ data and the output is the list of activated or dominant pathways in a given sample. Here we describe the first attempt to design and validate such...
Protein glycosylation is a common post-translational modification that is involved in many biological processes, including cell adhesion, protein–protein and receptor-ligand interactions. The glycoproteome constitutes a source for identification of disease biomarkers since altered protein glycosylation profiles are associated with certain human ailments. Glycoprotein analysis by mass spectrometry...
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