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Amyloid β-peptide (Aβ) plays an important role in the pathophysiology of Alzheimer's disease. The relationship between amnesia induced by central administration of aggregated Aβ(25-35) and neurodegeneration in the hippocampus was investigated. One month after a single intracerebroventricular injection of Aβ(25-35) (15 nmol), male Wistar rats were tested in an eight-arm radial maze. A quantitative...
Depression is frequently encountered during Parkinson's disease (PD) as a non-motor feature, which has been reported to cause and exaggerate motor deficits and neurodegenerative events in experimental PD models. We studied the effect of chronic mild stress (CMS) (pre, post and pre & post) exposure mediated depression on motor and non-motor symptoms, oxidative stress, inflammation and brain derived...
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