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We investigate the influence of des-Aspartate-angiotensin-I (DAA-I) on the cytokine expression profile in a rodent model of myocardial infarction. Myocardial infarction model was created in female Wistar rats by coronary artery ligation. Animals were randomized to receive intravenously either a daily dose of 1.2 μg DAA-I/kg body weight (group 1; n=60) or saline (group 2; n=60) for 14 days after infarction...
This study examined the role of interleukin (IL)-10 in angiotensin II-induced cardiac remodeling.Angiotensin II was infused subcutaneously (1.1mg/kg/day) for one week in IL-10 knockout and wild-type mice, after which cardiac function and hypertrophy were assessed by echocardiogram.IL-10 gene expression in the heart was increased by angiotensin II infusion. Plasma levels of brain natriuretic peptide...
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