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This article reviews the importance of the renin–angiotensin–aldosterone system (RAAS) in the cardiometabolic continuum; presents the pros and cons of dual RAAS blockade with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs); and examines the theoretical and practical benefits supporting the use of direct renin inhibitors (DRIs) in combination with ACEIs or...
We investigated the effects of soluble uric acid (UA) on the development of hypertension in spontaneously hypertensive rats (SHRs), using Wistar–Kyoto rats (WKY) as normotensive controls.UA was prepared freshly as a suspension in saline solution and administered twice daily, intraperitoneally, at a dose of 250mg/kg body weight for five weeks to SHR-UA (n=7) and WKY-UA rats (n=5). Controls for both...
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