Five new complexes, [Co 3 (HL 1 ) 2 (Py) 8 ]·4CH 3 OH (1), [Ni 3 (HL 1 ) 2 (Py) 4 ] 2 ·2DMF (2), [Co 3 (H 2 L 2 ) 2 (Py) 8 ]·2NO 3 (3), [Ni 2 (HL 2 )(Py) 6 ] (4) and [Cu 4 (HL 2 ) 2 (Py) 4 ]·4DMF (5) (H 4 L 1 =N-propionyl-4-hydroxysalicylhydrazide, H 4 4-hopshz; H 5 L 2 =N-(3-carboxy-cis-2-propenoyl)-4-hydroxysalicylhydrazide, H 5 4-hocpshz) have been obtained from two N,N′-diacylhydrazide ligands and characterized by elemental analysis, FT-IR, X-ray diffraction and antimicrobial activities. These di-, tri-, and tetrameric complexes are connected into three-dimensional supramolecular architectures with interesting topologies through O–H⋯O, C–H⋯O and C–H⋯π interactions. 1–3 are linear trimeric complexes with the ligands triply-deprotonated. Topological analysis indicates that they exhibit 2D (4,4), 3D (6,8)-connected (3 3 4 9 5 2 6)(3 4 4 12 5 7 6 4 7) and 8-connected (4 25 6 3 ) net, respectively. 4 and 5 possess dimeric and tetrameric structures, which are extended into 7-connected (3 3 4 13 5 3 6) and 4-connected (4,4) net, respectively.