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Manifold examples from the current biological literature describe the application of integrative analysis methods. These examples demonstrate the need for bioinformatics methods that integrate data from diverse sources and data that have heterogeneous formats. The requirements of such methods can be demonstrated through examples of applications used to analyze high-throughput data (particularly gene...
Colin Hill is the founder of Gene Network Sciences (GNS; http://www.gnsbiotech.com) and serves as President and Chief Executive Officer. He has extensive scientific experience in the areas of gene network modeling, pioneering the application of methods based in statistical physics and non-linear dynamics to the stochastic dynamics of gene expression. He is the co-founder of a multidisciplinary research...
Paper-based methods of clinical data collection, analysis and management have long been standard practice, but the development of online software solutions and the ubiquitous presence of the internet create opportunities to improve these processes. Adoption rates of the new technologies have been slow as result of in part resistance to change, but use of electronic solutions is on the upswing. The...
Predictive biosimulation provides the unique ability to explore, in a human in vivo context, the potential impact of novel or known targets on clinical outcome. This approach also allows the identification and exploration of knowledge gaps, leading to a better understanding of disease pathophysiology, and can focus laboratory experimentation on the crucial pathways involved in the disease, making...
A solid definition and comprehensive graphical representation of biological networks is essential for efficient and accurate dissemination of information on biological models. Several proposals have already been made toward this aim. The most well known representation of this kind is a molecular interaction map, or 'Kohn Map'. However, although the molecular interaction map is a well-defined and compact...
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