Batholiths from the accreted terranes in the Urals were generated by repeated episodes of melting and intrusion. Verkhisetsk, the largest and one of the most complex subduction-related batholiths from the Urals, comprises an outer envelope of older tonalites, trondhjemites and granodiorites dated at 315-320 Ma and equilibrated at 6 kbar, intruded by an inner core of younger granodiorites, adamellites and granites dated at 275-290 Ma and equilibrated at 4 kbar. Older rocks have a high-Al TTD/adakite chemistry, 3 2 0 M a c h u r (Nd) 2-5, and initial 8 7 Sr/ 8 6 Sr 0.7043, with pronounced lateral zoning marked by the increase of LREE/HREE, Cr, Ni, and Mg eastwards. They were originated by melting of metabasalts in a subducted slab of young hot oceanic lithosphere with a temperature/depth trajectory that intersected the garnet-in univariant at 1050°C and 13 kbar, thus causing the lateral zoning. We believe that such a warm trajectory can be attributed to the oblique subduction of a young lithosphere. Younger rocks range from Na-rich metaluminous granodiorites to K-rich peraluminous two-mica granites with relict epidote crystals, and have almost the same isotopic signature as older rocks, from which they were generated by anatexis as a consequence of a melting event that occurred throughout the Urals at 275-290 Ma and produced most of the huge continental-type batholiths on the eastern side. This melting event is tentatively supposed to be the result of underplating by mafic magmas, which also caused the growth of the Urals crust from the Moho downwards until it reached the increased thickness revealed by seismological studies.