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Salvinorin A was quantitated in human and rhesus monkey plasma, rhesus monkey cerebrospinal fluid, and human urine by negative ion LC–MS/APCI. The method for Salvinorin A has been fully validated, the LLOQ using FDA guidelines is 2ng/mL for 0.5mL plasma samples. The linear range was from 2 to 1000ng/mL. Several derivatives in the Salvinorin family can also be analyzed by this method; d 3 -Salvinorin...
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