This chapter provides an overview of liver lesions in returned travellers. Symptoms suggestive of liver disease include right upper quadrant abdominal pain, nausea, vomiting, and sometimes fever. Some liver lesions are asymptomatic and detected incidentally. Important lesions in febrile returned travellers are amoebic and bacterial liver abscesses. Others, such as tuberculosis and hydatid disease, are more common in migrants and much less often acquired during holiday travel or short stays abroad. Finally, more unusual parasitic infections, such as liver fluke, occasionally present as liver lesions in travellers.