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Propofol causes pain and clinically far less relevant, hypotension on injection. Both magnesium (Mg) and ketamine are an antagonist of the N-methyl-d-aspartate (NMDA) receptor ion channel. In view of the analgesic activity of Mg and ketamine, we tested the hypothesis that i.v. magnesium sulphate would be equally effective with ketamine in reducing pain due to propofol injection.Two hundred ASA I–III...
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