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Esmirtazapine (Org 50081), a high-affinity antagonist at 5-HT 2A and H 1 receptors, was assessed for its hypnotic efficacy.In this double-blind, randomized study, non-elderly patients with primary insomnia (but otherwise healthy) were treated with esmirtazapine (1.5, 3.0, or 4.5 mg) or placebo for two weeks. The primary end point was patient-reported total sleep time (TST); other patient–reported...
Esmirtazapine (Org 50081), a medication that binds with high affinity to serotonin 5-HT 2A and histamine-1 receptors, was evaluated as a potential treatment for insomnia.Adults with primary insomnia were treated with esmirtazapine (3.0 or 4.5 mg) or placebo in this 6-week, double-blind, randomized, polysomnography (PSG) study. The end points included wake time after sleep onset (WASO) (primary),...
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