Delivering health information and referrals through 2-1-1 is promising, but these systems need efficient ways of identifying callers at increased risk. This study explores the utility of using 2-1-1 service request data to predict callers' cancer control needs. Using data from a large sample of callers (N=4101) to United Way 2-1-1 Missouri, logistic regression was used to examine the relationship between caller demographics and type of service request, and cancer control needs. Of six types of service requests examined, three were associated with one or more cancer control needs. Two of the service request types were associated also with health insurance status. Findings suggest routinely collected 2-1-1 service request data may be useful in helping to efficiently identify callers with specific cancer prevention and control needs. However, to apply this approach in 2-1-1 systems across the country, further research and ongoing surveillance is necessary.