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In this study, individual treatments of human lymphocytes with Ni(II) [0.5-25 μM], Cr(VI) [0.65-1.30 μM], UV-light or X-rays induced SCEs in a dose-dependent fashion, and combined treatments of Ni(II) with Cr(VI), UV-light or X-rays interacted antagonistically. Nickel, at environmentaly relevant exposure levels, cna have the effect in complex mixtures of reducing an otherwise positive SCE response...
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