The aim of the study was to see whether a new technique of a neck dissection applying an ultrasonic activated (harmonic) scalpel would improve patient recovery.A prospective, non-randomized study was undertaken on 40 supraomohyoid neck dissections performed using a harmonic scalpel (20 pts) or electrocoagulation (20 pts). The evaluation included: operation time, intraoperative blood loss, postoperative seroma formation and pattern of wound healing.The operative time (mean±SD) using a harmonic scalpel was significantly shorter (52±10min vs. 86±22min; p⩽0.001) and the blood loss was less (13±7ml vs. 85±58ml; p⩽0.001), neck drainage on the first and second postoperative days were significantly smaller after using the ultrasonic scalpel (30±26ml; 44±23ml vs. 77±65ml; 118±66ml, p⩽0.001). Wound healing complications amounted to only 5% (20% in the control group).The use of the harmonic scalpel during neck dissection led to diminished bleeding, shorter operative time, lesser seroma formation and better wound healing in the postoperative period.