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Transforming growth factor β (TGFβ) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFβ receptors (TβRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFβ1 inhibits and HGF induces proliferation; (3) TGFβ1 and activin-A equipotently inhibit HGF secretion more than BMP-2,...
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