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Amphiregulin (AR) is a growth regulatory glycoprotein with significant amino acid homology to members of the epidermal growth factor (EGF) family. Its effects are mediated via the EGF receptor tyrosine kinase or through specific nuclear targeting sequences. In this study, the localization of immunoreactive AR was examined in paraformaldehyde glutaraldehyde fixed, paraffin-embedded human placentae...
We studied the expression of mRNA encoding the a- and β-subunts of marmoset chrrionic gonadotrophin (mCG) in implantation stage blastocysts and in a tropho-blastic cell line derived from such blastocysts. In this investigation in situ hybridization was carried out using digoxygenin-labelled riboprobes to localize the subunit transcripts. The trophoblastic cell line, known to secrete bioactive mCG,...
Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by preeclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoassay in the placenta and fetal membranes from 13 pregnancies complicated by pre-eclampsia...
The present study aims at the role of ferritin in the regulation of syncytiotrophoblast free iron levels. The differentiated cytotrophoblast cell in culture is used as a model for this maternal fetal interface. Cytotrophoblast cells isolated from term placentae are cultured in iron poor (Medium 199), iron-depleted [desferrioxamine(DFO)] and iron-supplemented (diferric transferrin (hTf-2Fe), ferric...
Addition of chlorpromazine (CPZ) of 100 μm final concentration to fragments of primordial human placenta incubated in vitro with [ 3 H]glycerol results in the following changes in the labelling of various neutral lipids and phospholipids: (1) rapid accumulation of [ 3 H]phosphatidic acid (PA) to a 2.31 +/- 0.12 fold (mean +/- s.d., P<0.05) higher steady-state level within 5 min;...
Cytomegalovirus (CM V) is one of the most frequent causes of intrauterine-acquired infection in the human species. However, very little is known about the pathophysiology of the transplacental transmission of the virus from the mother to the fetus. In this study, the passage of CM V across the human term placenta, and the susceptibility of the human term trophoblast to infection with CM V was investigated...
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