Obsessive-compulsive disorder (OCD) is characterized by the presence intrusive thoughts (obsessions) that cause anxiety in patients. Patients then perform various types of rituals (compulsions) to suppress symptoms of anxiety. OCD differ from other anxiety disorders. In OCD patients, the anxiety is caused by individual's specific situation. Aim of our study was to compare EEG signal during resting state, authobiographic scenario and general anxiety scenario.Resting-state eyes-closed EEG data were recorded in twenty OCD patients and fifteen healthy controls that were involved in the study. Cortical EEG sources were estimated by standardized low-resolution electromagnetic tomography (sLORETA) in seven frequency bands: delta (1.5–6Hz), theta (6.5–8Hz), alpha-1 (8.5–10Hz), alpha-2 (10.5–12Hz), beta-1 (12.5–18Hz), beta-2 (18.5–21Hz) and beta-3 (21.5–30Hz). Cognitive performance was measured by the Trail-Making Test (version A and B). Emotional states were induced by using two different scenarios. One of them was autobiographical (related to OCD symptoms of the patient) and the other aimed to induce general anxiety.Our results show different activation during exposure autobiographical and generally anxiety scenario in patients with OCD. During the exhibition, generally anxious scenario the activity changed in temporo-parietal areas both in OCD patients and healthy controls. Whereas during the exposition to autobiographical scenario we found activity changes in frontal areas.Our results suggest differences in the activation of brain structures when exposed to specific and non-specific anxiety in OCD patients.