The autothermal reforming and partial oxidation of hexadecane via Pt/Ni bimetallic nanoparticles on various ceria-based supports were investigated. Nanoparticles with Pt/Ni molar ratios ranging from 0/100 to 10/90 were loaded on ceria-based supports including cerium oxide, gadolinium-doped cerium oxide and cerium-doped zirconium oxide. The effect of the Pt/Ni molar ratio and the promotional effect of the support were studied by comparing the hydrogen yield. TPR and XPS analysis showed that there was a strong interaction between Ni and the CeO 2 –ZrO 2 support, which led to the enhancement of catalyst performance when the Pt/Ni ratio was low. In the case of bimetallic catalysts loaded on Gd 2 O 3 –CeO 2 , no significant improvement of the catalytic activity of auto-thermal reforming was achieved until the Pt/Ni ratio reached 10/90.