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Objectives: 11β-Hydroxysteroid dehydrogenase (11β-HSD) enzymes interconvert active cortisol and inactive cortisone. There is growing evidence that local tissue concentrations of cortisol are generally modulated by site specific different 11β-HSD actions. While 11β-HSD type 2 unidirectionally inactivates cortisol, type 1 isoform acts bidirectionally. 11β-HSD type 1 is mainly localized in the liver...
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