Values of in vitro air to liver partition coefficients, K liver , of VOCs have been collected from the literature. For 124 VOCs, application of the Abraham solvation equation to logK liver yielded a correlation equation with R 2 =0.927 and SD=0.26 log units. Combination of the logK liver values with logK blood values leads to in vitro blood to liver partition coefficients, as logP liver for VOCs; an Abraham solvation equation can correlate 125 such values with R 2 =0.583 and SD=0.23 log units. Values of in vivo logP liver for 85 drugs were collected, and were correlated with R 2 =0.522 and SD=0.42 log units. When the logP liver values for VOCs and drugs were combined, an Abraham solvation equation could correlate the 210 compounds with R 2 =0.544 and SD=0.32 log units. Division of the 210 compounds into a training set and a test set, each of 105 compounds, showed that the training equation could predict logP liver values with an average error of 0.05 and a standard deviation of 0.34 log units.