Medical Hypotheses

Items from 1 to 20 out of 30 results

article

Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes?

Chandika Damesh Gamage, Yomani Dilukshi Sarathkumara

Medical Hypotheses > 2016 > 91 > C > 16-19

Chronic kidney disease of uncertain etiology (CKDu) has been a severe burden and a public health crisis in Sri Lanka over the past two decades. Many studies have established hypotheses to identify potential risk factors although causative agents, risk factors and etiology of this disease are still uncertain. Several studies have postulated that fungal and bacterial nephrotoxins are a possible etiological...

article

A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton’s base reservoir with net base-producing diets

Anthony Sebastian, Lynda A. Frassetto

Medical Hypotheses > 2016 > 91 > C > 103-108

Osteoporosis is a disorder of bone in which the mass of the bone is reduced and the bone’s architecture at the microscopic level is disordered. Together those abnormalities predispose affected individuals to experience fractures despite only minimal trauma (i.e., fragility fractures). Age related osteoporosis is a common type of osteoporosis that occurs with aging in both men and women usually beginning...

article

From organophosphate poisoning to diabetes mellitus: The incretin effect

D. Rathish, S.B. Agampodi, M.A.C.S. Jayasumana, S.H. Siribaddana

Medical Hypotheses > 2016 > 91 > C > 53-55

Organophosphate (OP) poisoning induced disruption of glucose homeostasis is well established. OP poisoning leads to accumulation of acetylcholine (ACh) due to the inhibition of acetylcholinesterases (AChE). On the other hand the incidence of type 2 diabetes mellitus (T2DM) is shown to rise along with the use of pesticides in Southeast Asia. Attenuation of the ‘incretin effect’ is seen in T2DM. This...

article

The future of neonatal BCG

Michel R. Odent

Medical Hypotheses > 2016 > 91 > C > 34-36

We hypothesise that neonatal BCG (Bacillus Calmette–Guérin) might be used to adapt to a new phase in the history of human births.Among most mammals, the placenta is not effective at transferring antibodies to the fetus: antibodies are transferred immediately after birth via the colostrum. Among humans (and other mammals with hemochorial placentas) the transplacental transfer of antibodies (namely...

article

Asthma-COPD Overlap Syndrome (ACOS): Single disease entity or not? Could exhaled nitric oxide be a useful biomarker for the differentiation of ACOS, asthma and COPD?

Theodoros Karampitsakos, Konstantinos I. Gourgoulianis

Medical Hypotheses > 2016 > 91 > C > 20-23

Asthma and chronic obstructive pulmonary disease (COPD) represent two major public health problems. However, there is a significant proportion of patients with a mixed asthma-COPD phenotype. This condition is defined as asthma-COPD overlap syndrome (ACOS). Since there are no internationally accepted criteria for the diagnosis of that syndrome, its management remains difficult. Given the fact that...

article

Title page/Editorial Board

Medical Hypotheses > 2016 > 91 > C > i

article

Virtual implantation and patient-specific simulation for optimization of outcomes in ventricular assist device recipients

Amedeo Anselmi, Sophie Collin, Pascal Haigron, Jean-Philippe Verhoye, more

Medical Hypotheses > 2016 > 91 > C > 67-72

Left ventricular assist devices (LVAD) are increasingly used for long-term mechanical circulatory support and are effective in improving survival and quality-of-life of patient with advanced heart failure. Nonetheless, they are associated with significant early and late morbidity rates (including pump thrombosis, thromboembolic events, and pump dysfunction). These complications are at least partially...

article

Dilating venous disease: Pathophysiology and a systematic aspect to different vascular territories

Ertan Yetkin, Mehmet Ileri

Medical Hypotheses > 2016 > 91 > C > 73-76

Venous disease is a common but overlooked clinical problem and is an important mortality and morbidity factor depending on the effected vascular territory. Different contributing factors play role on the clinical manifestation of the disease. Peripheral varices of lower extremities, hemorrhoids, varicoceles, pelvic varicose veins are the vasculopathy of veins running toward heart but against gravity...

article

The influence of systemic circulation on hearing: The reliability of a different impact of microcirculatory defects and atherosclerosis

Antonio Pirodda, Cristina Brandolini, Claudio Borghi

Medical Hypotheses > 2016 > 91 > C > 6-8

The extension of the dependence of hearing acuity from circulatory factors has been widely evaluated in the literature, without reaching an univocal conclusion. In our opinion, a precise distinction between acute/fluctuating disorders and progressive hearing loss must be made in order to identify the possible circulatory causes. Actually, it is conceivable to hypothesize that an acute lack of perfusion...

article

Causation model of autism: Audiovisual brain specialization in infancy competes with social brain networks

Karen Frankel Heffler, Leonard M. Oestreicher

Medical Hypotheses > 2016 > 91 > C > 114-122

Earliest identifiable findings in autism indicate that the autistic brain develops differently from the typical brain in the first year of life, after a period of typical development. Twin studies suggest that autism has an environmental component contributing to causation. Increased availability of audiovisual (AV) materials and viewing practices of infants parallel the time frame of the rise in...

article

Parallels between phantom pain and tinnitus

Selcuk Peker, Alperen Sirin

Medical Hypotheses > 2016 > 91 > C > 95-97

Phantom pain and tinnitus are diseases that cause patients great discomfort. Both are phantom sensations that have many connections with cerebral structures, but their underlying mechanisms are not fully understood. Several therapies have been suggested for these conditions over the years, but there is still no consensus on how to treat either one. Comparison of these two phenomena reveals many similarities,...

article

Morphogenesis of the demyelinating lesions in Baló’s concentric sclerosis

Helmut Barz, Ulrich Barz, Almut Schreiber

Medical Hypotheses > 2016 > 91 > C > 56-61

In tissues with elastic properties, an edema causes a raised tissue pressure and therefore a diminished blood flow. The authors assume that an increased tissue pressure due to local and/or relapsing edema may be the cause for incomplete necrosis (e.g. demyelinated lesions) or seldom complete necrosis in the brain.Newly forming demyelinating lesions seldom show small tissue bands with normal appearing...

article

Corrigendum to ‘Optimal inference with suboptimal models: Addiction and active Bayesian inference’ [Med. Hypotheses 84 (2015) 109–117]

Philipp Schwartenbeck, Thomas H.B. FitzGerald, Christoph Mathys, Ray Dolan, more

Medical Hypotheses > 2016 > 91 > C > 123

article

Hepatitis B viral infection of hepatic progenitor cells. Resolving unresolved questions?

G.Y. Minuk, Y. Baruch

Medical Hypotheses > 2016 > 91 > C > 24-27

Accumulated data to date do not entirely explain the; propensity of the hepatitis B virus (HBV) to cause chronic infections in newborns; failure of antiviral agents to resolve infections or precise mechanism whereby HBV causes hepatocellular carcinoma (HCC). Based on the increased numbers of hepatic stem/progenitor cells (HPCs) present within the neonatal liver, the refractoriness of these cells to...

article

Mortality reduction among persons with type 2 diabetes: (−)-Epicatechin as add-on therapy to metformin?

Aldo Moreno-Ulloa, Javier Moreno-Ulloa

Medical Hypotheses > 2016 > 91 > C > 86-89

Diabetes has become a worldwide epidemic, and is growing at a rapid rate with drastic projections for developing countries. Mexico occupies the ninth place worldwide for type 2 diabetes prevalence, and in the foreseeable future, it is expected rise to the seventh place. Myocardial infarction is the most common cause of death in these patients. Although several drugs are approved for the treatment...

article

Tyrosinase, could it be a missing link in ochronosis in alkaptonuria?

Adam M Taylor, Vishnu Kammath, Aaron Bleakley

Medical Hypotheses > 2016 > 91 > C > 77-80

The hypothesis that is proposed is that tyrosinase, an enzyme widely found within the human body is implicated in the ochronosis that occurs in alkaptonuria; an autosomal recessive condition first used by Archibald Garrod to describe the theory of “Inborn Errors of Metabolism.” The disease results from the absence of a single enzyme in the liver that breaks down homogentisic acid; this molecule becomes...

article

A multipronged, nutritional-based strategy for managing Alzheimer’s disease

J. Leslie Glick, Philip A. McMillan

Medical Hypotheses > 2016 > 91 > C > 98-102

A nutritional-based strategy has been proposed in order to improve cognitive performance of Alzheimer’s disease (AD) patients. The strategy requires daily dietary supplementation with magnesium (Mg), folic acid, and vitamins B6 and B12, daily consumption of silicic acid-rich mineral water in order to lower the body burden of Al, and several plasma exchange procedures in order to replace Aβ-bound albumin...

article

Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein–Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis

Carolin Otto, Jörg Hofmann, Klemens Ruprecht

Medical Hypotheses > 2016 > 91 > C > 109-113

Patients with multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS), typically have an intrathecal synthesis of immunoglobulin (Ig)G. Intrathecal IgG is produced by B lineage cells that entered the CNS, but why and when these cells invade the CNS of patients with MS is unknown. The intrathecal IgG response in patients with MS is polyspecific and part of it is...

article

Speckle tracking technology for quantifying lung sliding

Guy Dori, Daniel J. Jakobson

Medical Hypotheses > 2016 > 91 > C > 81-83

Ultrasound (US) is gaining recognition as a useful tool for assessing lung physiology and pathology. Yet, currently the skill of performing lung US is taught by experienced operators to novice ones, mainly by recognizing expected patterns. Recognizing the latter may be difficult and subjective. In this hypothesis we propose to apply a well-known and used image processing technology in echocardiography,...

article

Migraine as dysfunctional drive reduction: Insight from electrophysiology

Goded Shahaf

Medical Hypotheses > 2016 > 91 > C > 62-66

Migraine is a prevalent disease, which may cause significant discomfort and reduced functioning for days, including the preictal and postictal periods. During the interictal period, however, migraineurs seem to function normally. It is puzzling, therefore, that event-related potentials (ERPs) of migraine patients often differ at the group level also in the asymptomatic, interictal phase, both in early...

Volume:
91
Year:
2016

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Keywords

ACETYLCHOLINE (1)
ANTIBODIES (1)
ANTIBODY INDEX (1)
ASTHMA (1)
ASTHMA-COPD OVERLAP SYNDROME (1)
ATROPINE (1)
ATYPICAL SYMPTOMS (1)
AUTISM (1)
CALCIUM (1)
CEREBROSPINAL FLUID (1)
CERVICAL SPONDYLOSIS (1)
CHRONIC KIDNEY DISEASE OF UNCERTAIN ETIOLOGY (CKDU) (1)
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (1)
CLINICAL OUTCOMES (1)
COMPUTER-ASSISTED SURGERY (1)
DMT1 (1)
DRIVE REDUCTION (1)
EEG (1)
EPSTEIN–BARR VIRUS (1)
ERP (1)
FRACTIONAL EXHALED NITRIC OXIDE (1)
GLUCAGON LIKE PEPTIDE-1 (1)
GLUCOSE HOMEOSTASIS (1)
HANTAVIRUS (1)
HEME (1)
HEMORRHOID (1)
HEPATITIS B TREATMENT (1)
HEPATITIS B VIRUS (1)
HEPATOCELLULAR CARCINOMA AND VIRAL HEPATITIS (1)
INCRETINS (1)
LEFT VENTRICULAR ASSIST DEVICE (1)
LEPTOSPIROSIS (1)
LUNG SLIDING (1)
LUNG ULTRASOUND (1)
MEASLES VIRUS (1)
MERCURY (1)
MIGRAINE (1)
MULTIPLE SCLEROSIS (1)
NEONATAL HEPATITIS (1)
OBESITY (1)
ORGANOPHOSPHATE (1)
OVERWEIGHT (1)
PELVIC CONGESTION SYNDROME (1)
PRENATAL MERCURY EXPOSURE (1)
PROGENITOR CELLS (1)
RUBELLA VIRUS (1)
SERUM (1)
SPECKLE TRACKING (1)
STEM CELLS (1)
STRESS (1)
TRPV6 (1)
TYPE 2 DIABETES MELLITUS (1)
VARICELLA ZOSTER VIRUS (1)
VARICOCELE (1)
VARICOSE VEIN (1)
VARIX (1)
VERTIGO (1)
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Medical Hypotheses

Chronic kidney disease of uncertain etiology in Sri Lanka: Are leptospirosis and Hantaviral infection likely causes?

A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton’s base reservoir with net base-producing diets

From organophosphate poisoning to diabetes mellitus: The incretin effect

The future of neonatal BCG

Asthma-COPD Overlap Syndrome (ACOS): Single disease entity or not? Could exhaled nitric oxide be a useful biomarker for the differentiation of ACOS, asthma and COPD?

Title page/Editorial Board

Virtual implantation and patient-specific simulation for optimization of outcomes in ventricular assist device recipients

Dilating venous disease: Pathophysiology and a systematic aspect to different vascular territories

The influence of systemic circulation on hearing: The reliability of a different impact of microcirculatory defects and atherosclerosis

Causation model of autism: Audiovisual brain specialization in infancy competes with social brain networks

Parallels between phantom pain and tinnitus

Morphogenesis of the demyelinating lesions in Baló’s concentric sclerosis

Corrigendum to ‘Optimal inference with suboptimal models: Addiction and active Bayesian inference’ [Med. Hypotheses 84 (2015) 109–117]

Hepatitis B viral infection of hepatic progenitor cells. Resolving unresolved questions?

Mortality reduction among persons with type 2 diabetes: (−)-Epicatechin as add-on therapy to metformin?

Tyrosinase, could it be a missing link in ochronosis in alkaptonuria?

A multipronged, nutritional-based strategy for managing Alzheimer’s disease

Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein–Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis

Speckle tracking technology for quantifying lung sliding

Migraine as dysfunctional drive reduction: Insight from electrophysiology

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