Government agencies can determine which specific facilities in a transportation network to restrict for each class of material and for which times of the day and/or week to stem the consequences of a terrorist event. To guide in making these determinations, this paper develops a three-player game of the interactions among a government agency, a carrier, and a terrorist. It also develops an effective solution procedure for this game and illustrates the use of that procedure on a realistic case study based on the freight rail network in the continental United States.