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Both oxotremorine and physostigmine both in doses ranging from 25 to 100 μg/kg produced dose-dependent attenuation of withdrawal jumping and potentiation of wet dog shakes, burrowing, hypothermia and body weight loss precipitated by naloxone (1 mg/kg, i.p.) in morphine-dependent mice. On the other hand, atropine sulphate (2-20 mg/kg) dose-dependently attenuated all naloxone precipitated withdrawal...
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