Three sensitive, selective, accurate spectrophotometric and spectrofluorimetric methods have been developed for the determination of ropinirole hydrochloride in tablets. The first method was based on measuring the absorbance of drug solution in methanol at 250nm. The Beer's law was obeyed in the concentration range 2.5–24μgml −1 . The second method was based on the charge transfer reaction of drug, as n-electron donor with 7,7,8,8-tetracyanoquinodimethane (TCNQ), as π-acceptor in acetonitrile to give radical anions that are measured at 842nm. The Beer's law was obeyed in the concentration range 0.6–8μgml −1 . The third method was based on derivatization reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) in borate buffer of pH 8.5 followed by measuring the fluorescence intensity at 525nm with excitation at 464nm in chloroform. Beer's law was obeyed in the concentration range 0.01–1.3μgml −1 . The derivatization reaction product of drug with NBD-Cl was characterized by IR, 1 H NMR and mass spectroscopy. The developed methods were validated. The following analytical parameters were investigated: the molar absorptivity (ɛ), limit of detection (LOD, μgml −1 ) and limit of quantitation (LOQ, μgml −1 ), precision, accuracy, recovery, and Sandell's sensitivity. Selectivity was validated by subjecting stock solution of ropinirole to acidic, basic, oxidative, and thermal degradation. No interference was observed from common excipients present in formulations. The proposed methods were successfully applied for determination of drug in tablets. The results of these proposed methods were compared with each other statistically.