Among HIV (+) patients treated with antiretroviral therapy lipolytic disorders called lipodystrophy have been described. Majority of patients with HAART-associated lipodystrophy are women. The symptoms of lipodystrophy manifests as: dorsocervical fat accumulation (“buffalo hump”), central adiposity, peripheral fat waisting (face, lower and upper limbs) and associated laboratory abnormalities such as hipertriglycerydemia with low HDL, elevated LDL and total cholesterol levels and insulin resistance or type II of diabetes mellitus. Treatment of patients with lipodystrophy is very difficult and must include specialized medical and dietary cares, accurate physiotherapy and psychological help. Appropriate exercises and diet should be considered as a part of the treatment. In this review we present problems, connected with physiotherapy of this group of patients in the light of the recent publications.