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Cultures of the marine fungus Hypoxylon oceanicum (LL-15G256) were found to have potent antifungal activity in assays designed to detect inhibitors of fungal cell wall biosynthesis. Bio-activity guided isolation provided the macrocyclic polyesters 15G256α (1), 15G256α-1 (2) and 15G256β (3) that were partially responsible for the antifungal activity. In addition, fermentation beers contained a series...
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