To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure.A total of 267 women [mean body mass index (BMI)=32.0±5.7kg/m 2 and mean age=57.3±6.6 years] underwent a 6-month exercise intervention program. Exercise training was performed 3–4 times per week at a targeted heart rate corresponding to 50% of the maximal oxygen consumption.Compared to baseline values, mean change in relative VO 2 max (the primary endpoint) was of 1.18±2.25mL/minkg (p<0.0001), mean weight loss was of 1.4±3.3kg (p<0.0001), mean reduction in waist circumference was of 2.4±6.9cm (p<0.0001) and systolic blood pressure did not change significantly (−1.2±13.0mmHg, NS). No changes were observed in markers of the lipoprotein-lipid profile. No changes were observed for plasma levels of C-reactive protein, interleukin-6, tumor-necrosis factor-α and adiponectin. Changes in VO 2 max were negatively associated with changes in body weight (r=−0.26, p<0.0001) and waist circumference (r=−0.16, p=0.01), but not with changes in cardiometabolic risk markers.Although exercise training significantly increased cardiorespiratory fitness in these sedentary, but metabolically healthy obese/overweight women with a moderately elevated systolic blood pressure, no significant improvements were observed in their cardiometabolic risk profile.