Background: Mild or overt hyperhomocysteinemia (hyperHCy) is recognized as an independent vascular risk factor. The aim of this study was to determine the efficiency of vitamin therapy in hyperHCy patients.Methods: In a prospective study, 17 hyperHCy patients (11 men and 6 women) with vascular events have received folic acid (5 mg/d) and B6 vitamin (250 mg/day). HyperHCy and vitamins levels were investigated either after 3 months (M3 in 7 cases) or 6 months (M6 in 10 cases). Initially and during follow-up fasting (FH) and post-load methionine (PLH) total plasma homocysteine (HCy) levels were measured together with seric (aFolS) and erythrocyte (aFolE) folic acid and plasmatic B12 vitamin (vitB12). Mean (± SD) age was 46.4 ± 13 y and BMI was 26.7 ± 6.3 kg/m2. Statistical analysis used Student t-test, regression analysis and p-levels < 0.05 were considered as significant.Results:Discussion: Folates and B6 vitamin in hyperHCy patients reverse hyperhomocysteinemia which levels return to normal values. Compliance is easy to check because folates are clearly enhanced whereas B12 vitamin is unchanged. Nevertheless, clinical benefits of vitamin therapy in such patients must be determined in long term studies.